Article
Genetic basis for kidney cancer: opportunity for disease-specific approaches to therapy.
Expert opinion on biological therapy - 1 Jun 2008
Pfaffenroth Elizabeth Cartwright, Linehan W Marston
Abstract excerpt
BACKGROUND: Kidney cancer is not a homogenous entity; it is comprised of many different tumor types, with different biologies and molecular mechanisms leading to disease and therefore different treatment approaches. OBJECTIVE: To describe the genetic basis and biochemical pathways underlying inherited forms of renal cancer, specifically in four described syndromes (von Hippel-Lindau [VHL], hereditary papillary...
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