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[Increased sensitivity for detection of mutations in exon 15 of the APC gene in patients with familial adenomatous polyposis].

Casopis lekaru ceskych - 1 Jan 2004

Konvalinka D, Bik E C, Tops C M, Bakker E, Singh A R, Vrtĕl R, Santavý J

Abstract excerpt

BACKGROUND: Protein Truncation Test (PTT) was used to detect mutations in exon 15 of the APC gene in patients with Familial Adenomatous Polyposis. This method is limited by its ability to detect polypetide chains up to a certain minimum length. The aim of this study was to increase the sensitivity of detection of mutations in this region by using the technique of Denaturing Gradient Gel Electrophoresis (DGGE)....

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Identifiers

PMID: 15446460

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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