Article
A critical appraisal of X-linked bipolar illness. Evidence for the assumed mode of inheritance is lacking.
The British journal of psychiatry : the journal of mental science - 1 Jan 1992
Hebebrand J
Abstract excerpt
The major assumption underlying all X-linkage studies of bipolar disorder has been that a subgroup of manic-depressive illness follows an X-linked dominant mode of inheritance. An evaluation of the segregation patterns in the pedigrees that have been analysed for X-linkage over the past 20 years does not support this assumption, because the formal genetic criteria for an X-linked dominant mode of inheritance are...
Topics
- Bipolar Disorder
- Genetic Linkage
- Genotype
- Humans
- Risk Factors
- Sex Chromosome Aberrations
- X Chromosome