Article
Daptomycin is highly efficacious against penicillin-resistant and penicillin- and quinolone-resistant pneumococci in experimental meningitis.
Antimicrobial agents and chemotherapy - 1 Oct 2004
Cottagnoud Philippe, Pfister Marc, Acosta Fernando, Cottagnoud Marianne, Flatz Lukas, Kühn Felix, Müller Hans-Peter, Stucki Armin
Abstract excerpt
The penetration of daptomycin, a new lipopeptide antibiotic, into inflamed meninges ranged between 4.37 and 7.53% (mean, 5.97%). Daptomycin was very efficacious in the treatment of experimental pneumococcal meningitis, producing a decrease of -1.20 +/- 0.32 Deltalog(10) CFU/ml. h in the bacterial titer of Streptococcus pneumoniae against a penicillin-resistant strain and of -0.97 +/- 0.32 Deltalog(10) CFU/ml. h...
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