Article
Interlocus nonrandom association of polymorphisms in Drosophila chemoreceptor genes.
Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2004
Takano-Shimizu Toshiyuki, Kawabe Akira, Inomata Nobuyuki, Nanba Noriko, Kondo Rumi, Inoue Yutaka, Itoh Masanobu
Abstract excerpt
Some forms of multilocus selection with epistasis, such as truncation selection, can effectively reduce the mutation load [Kondrashov, A. S. (1988) Nature 336, 435-440]. Many quantitative characters, including complex genetic diseases, are likely to be subject to these types of selection. However, direct measurement of selection in natural populations is difficult and the effect of epistasis on within-species...
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