Article
Non-linear selection response in Drosophila: a strategy for testing the rare-alleles model of quantitative genetic variability.
Genetica - 1 Jan 1997
Curtsinger J W, Ming R
Abstract excerpt
Quantitative genetic theory predicts that variation due to rare alleles at many loci will generate a transient acceleration in the response to directional selection. We have tested this prediction by constructing experimental lines of Drosophila melanogaster that carry positively selected ethanol resistance alleles at low frequencies, and then subjecting the lines to directional selection for ethanol resistance....
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