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Article

Association of CYP17 with HLA-B27-negative seronegative spondyloarthropathy in Japanese males.

American journal of medical genetics. Part A - 1 Oct 2004

Mori Kanji, Kizawa Hideki, Ushiyama Toshio, Chano Tokuhiro, Inoue Hisashi, Tsuchiya Naoyuki, Okabe Hidetoshi, Matsusue Yoshitaka, Ikegawa Shiro

Abstract excerpt

Susceptibility genes for seronegative spondyloarthropathy (SNSA) other than HLA-B27 remain unclarified. Sex hormones are implicated in the pathogenesis of SNSA. Cytochrome P450c17a (CYP17) is a key regulator of androgen biosynthesis, and a single nucleotide polymorphism (SNP) in the 5'-untranslated region of the CYP17 gene (CYP17), -34C > T, is associated with variety of diseases. We have investigated the...

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Identifiers

PMID: 15372520
DOI: 10.1002/ajmg.a.30259

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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