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Article

Multivesicular body-ESCRT components function in pH response regulation in Saccharomyces cerevisiae and Candida albicans.

Molecular biology of the cell - 1 Dec 2004

Xu Wenjie, Smith Frank J, Subaran Ryan, Mitchell Aaron P

Abstract excerpt

The ESCRT-I, -II, and -III protein complexes function to create multivesicular bodies (MVBs) for sorting of proteins destined for the lysosome or vacuole. Prior studies with Saccharomyces cerevisiae have shown that the ESCRT-III protein Snf7p interacts with the MVB pathway protein Bro1p as well as its homolog Rim20p. Rim20p has no role in MVB formation, but functions in the Rim101p pH-response pathway; Rim20p...

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Source

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Identifiers

PMID: 15371534
DOI: 10.1091/mbc.e04-08-0666
PMCID: PMC532031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Multivesicular body-ESCRT components function in pH response regulation in Saccharomyces cerevisiae and Candida albicans.PMID 15371534Read ↗

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Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway.Semantic proximity Read ↗

Mutational analysis of Candida albicans SNF7 reveals genetically separable Rim101 and ESCRT functions and demonstrates divergence in bro1-domain protein interactions.Semantic proximity Read ↗

Snf7p, a component of the ESCRT-III protein complex, is an upstream member of the RIM101 pathway in Candida albicans.Semantic proximity Read ↗

Deletions of endocytic components VPS28 and VPS32 affect growth at alkaline pH and virulence through both RIM101-dependent and RIM101-independent pathways in Candida albicans.Semantic proximity Read ↗

ESCRT-I components of the endocytic machinery are required for Rim101-dependent ambient pH regulation in the yeast Yarrowia lipolytica.Semantic proximity Read ↗

Analysis of the dual function of the ESCRT-III protein Snf7 in endocytic trafficking and in gene expression.Semantic proximity Read ↗

Ambient pH signalling in the yeast Yarrowia lipolytica involves YlRim23p/PalC, which interacts with Snf7p/Vps32p, but does not require the long C terminus of YlRim9p/PalI.Semantic proximity Read ↗

The pH-sensing Rim101 pathway positively regulates the transcriptional expression of the calcium pump gene PMR1 to affect calcium sensitivity in budding yeast.Semantic proximity Read ↗

RIM101-dependent and-independent pathways govern pH responses in Candida albicans.Semantic proximity Read ↗

Endosomal Na+ (K+)/H+ exchanger Nhx1/Vps44 functions independently and downstream of multivesicular body formation.Semantic proximity Read ↗

ESCRT components regulate the expression of the ER/Golgi calcium pump gene PMR1 through the Rim101/Nrg1 pathway in budding yeast.Semantic proximity Read ↗

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