Article
C825T polymorphism in the human G protein beta 3 subunit gene and preeclampsia; a case control study.
Hypertension in pregnancy - 1 Jan 2004
Jansen Mieke W J C, Bertina Rogier M, Vos Hans L, Bloemenkamp Kitty W M, Helmerhorst Frans M, Wladimiroff Juriy W, de Groot Christianne J M
Abstract excerpt
OBJECTIVE: Recently, a polymorphism of the gene encoding for the G protein beta3-subunit (GNB3) has been described. The T allele of this polymorphism (825T) is associated with endothelium dysfunction. Endothelium dysfunction has been described in women with preeclampsia. We, therefore, tested the hypothesis that in women who have had preeclampsia the T allele is more prevalent than in controls. STUDY DESIGN: We...
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