Article
Correlation between factor VIII genotype and inhibitor development in hemophilia A.
Seminars in thrombosis and hemostasis - 1 Jan 2000
Fakharzadeh S S, Kazazian H H
Abstract excerpt
The development of neutralizing antibodies, or inhibitors, against infused factor VIII represents a significant complication of treatment for hemophilia A. Although it is likely that both genetic and environmental factors influence whether patients form inhibitors, correlations between types of factor VIII mutations and inhibitor development are becoming apparent. Approximately 20% of all patients with severe...
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