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Article

Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells.

Oncogene - 11 Apr 2002

Horie Ryouichi, Watanabe Takuro, Morishita Yasuyuki, Ito Kinji, Ishida Takaomi, Kanegae Yumi, Saito Izumu, Higashihara Masaaki, Mori Shigeo, Kadin Marshall E, Watanabe Toshiki

Abstract excerpt

Overexpression of CD30 and constitutive NF-kappaB activation characterizes tumor cells of Hodgkin's disease (HD), Hodgkin and Reed-Sternberg (H-RS) cells. We report that in H-RS cells overexpression of CD30 leads to self-aggregation, recruitment of TRAF2 and TRAF5, and NF-kappaB activation, independent of CD30 ligand. CD30 and TRAF proteins co-localized in H-RS cell lines and in lymph nodes of HD. An...

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Identifiers

PMID: 11971184
DOI: 10.1038/sj.onc.1205337

Genes

TRAF2
TRAF5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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