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Article

Secretion of sterols and the NPC2 protein from primary astrocytes.

The Journal of biological chemistry - 19 Nov 2004

Mutka Aino-Liisa, Lusa Sari, Linder Matts D, Jokitalo Eija, Kopra Outi, Jauhiainen Matti, Ikonen Elina

Abstract excerpt

Astrocytes secrete cholesterol in lipoprotein particles. Here we show that primary murine embryonic astrocytes secrete endogenously synthesized cholesterol but also the cholesterol precursors desmosterol and lathosterol. In astrocyte membranes, desmosterol and cholesterol were the predominant sterols. Astrocytes derived from Niemann-Pick type C lipidosis (NPC1-/-) mice displayed late endosomal cholesterol...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15355983
DOI: 10.1074/jbc.M405345200

Genes

NPC2
NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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