Article
Interaction of the BMPR-IA tumor suppressor with a developmentally relevant splicing factor.
Biochemical and biophysical research communications - 8 Oct 2004
Nishanian Tagvor G, Waldman Todd
Abstract excerpt
Inactivation of bone morphogenetic protein signaling via mutation of the BMPR-IA TGF-beta superfamily type I receptor causes familial juvenile polyposis, an inherited gastrointestinal cancer predisposition syndrome. In an effort to provide new insight into the mechanism(s) of BMP-mediated tumor suppression, we employed a yeast two-hybrid screen to identify novel proteins that interact with the intracellular...
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