Article
The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex.
Investigative ophthalmology & visual science - 1 Jul 2008
Hidalgo-de-Quintana Juan, Evans R Jane, Cheetham Michael E, van der Spuy Jacqueline
Abstract excerpt
PURPOSE: AIPL1 mutations cause the severe inherited blindness Leber congenital amaurosis (LCA). The similarity of AIPL1 to tetratricopeptide repeat (TPR) cochaperones that interact with the chaperone Hsp90 and the ability of AIPL1 to suppress the aggregation of NUB1 fragments in a chaperone-like manner suggest that AIPL1 might function as part of a chaperone heterocomplex facilitating retinal protein maturation....
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