Article
Immune response to Mycoplasma pulmonis in nasal mucosa is modulated by the normal microbiota.
American journal of respiratory cell and molecular biology - 1 Dec 2004
Henriksson Gert, Helgeland Lars, Midtvedt Tore, Stierna Pontus, Brandtzaeg Per
Abstract excerpt
The impact of commensal bacteria on lymphocyte responses in the upper airways was studied in rat nasal mucosa after infection with the pathogen Mycoplasma pulmonis. Phenotyping was performed in situ by paired immunofluorescence staining in germ-free (GF) and conventional (CV) rats before and 3 wk after the monoinfection. Intraepithelial lymphocytes had expanded significantly in GF (P = 0.02) but not in CV rats....
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