Article
A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs.
Mechanisms of development - 1 Oct 2004
Willingham Aarron T, Keil Thomas
Abstract excerpt
Cytochrome P450s have generally been acknowledged as broadly tuned detoxifying enzymes. However, emerging evidence argues P450s have an integral role in cell signaling and developmental processes, via their metabolism of retinoic acid, arachidonic acid, steroids, and other cellular ligands. To study the morphogenesis of Drosophila sensory organs, we examined mutants with impaired mechanosensation and discovered...
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