Article
Post-transplantation tumour load in bone marrow, as assessed by quantitative ASO-PCR, is a prognostic parameter in multiple myeloma.
British journal of haematology - 1 Sept 2004
Bakkus Marleen H C, Bouko Yasmina, Samson Diana, Apperley Jane F, Thielemans Kris, Van Camp Benjamin, Benner Axel, Goldschmidt Hartmut, Moos Marion, Cremer Friedrich W
Abstract excerpt
High-dose therapy (HDT) and autologous transplantation prolongs remission duration and survival in multiple myeloma (MM), but relapse still occurs at a median of 2 years post-HDT. In order to investigate whether the number of residual tumour cells in the bone marrow (BM) after transplantation can predict the duration of response, a quantitative allele-specific oligonucleotide polymerase chain reaction (qASO-PCR)...
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