Article
Coexposure to benzo[a]pyrene plus UVA induced DNA double strand breaks: visualization of Ku assembly in the nucleus having DNA lesions.
Biochemical and biophysical research communications - 17 Sept 2004
Toyooka Tatsushi, Ibuki Yuko, Koike Manabu, Ohashi Norio, Takahashi Sentaro, Goto Rensuke
Abstract excerpt
Benzo[a]pyrene (BaP) is a ubiquitous environmental pollutant with potential carcinogenicity. It has been shown that BaP, upon UVA irradiation, synergistically induced oxidative DNA damage, but other DNA damage was not confirmed. In this study, we examined whether coexposure to BaP plus UVA induces double strand breaks (DSBs) using xrs-5 cells, deficient in the repair of DSBs (Ku80 mutant), and whether Ku...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.