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Article

Environmental exposure and HPV infection may act synergistically to induce lung tumorigenesis in nonsmokers.

Oncotarget - 12 Apr 2016

Cheng Ya-Wen, Lin Frank Cheau-Feng, Chen Chih-Yi, Hsu Nan-Yung

Abstract excerpt

Most studies of lung tumorigenesis have focused on smokers rather than nonsmokers. In this study, we used human papillomavirus (HPV)-positive and HPV-negative lung cancer cells to test the hypothesis that HPV infection synergistically increases DNA damage induced by exposure to the carcinogen benzo[a]pyrene (B[a]P), and contributes to lung tumorigenesis in nonsmokers. DNA adduct levels induced by B[a]P in...

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Share to Benzo(a)pyrene
Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ku Autoantigen

Share to Oncogene Proteins, Viral

Share to Papillomavirus Infections

Source

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Identifiers

PMID: 26918347
DOI: 10.18632/oncotarget.7628
PMCID: PMC4991423

Genes

XRCC5
XRCC3
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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