Article
Identification of gene polymorphism in lipocalin-type prostaglandin D synthase and its association with carotid atherosclerosis in Japanese hypertensive patients.
Biochemical and biophysical research communications - 17 Sept 2004
Miwa Yoshikazu, Takiuchi Shin, Kamide Kei, Yoshii Masayoshi, Horio Takeshi, Tanaka Chihiro, Banno Mariko, Miyata Toshiyuki, Sasaguri Toshiyuki, Kawano Yuhei
Abstract excerpt
Recent reports suggested that lipocalin-type prostaglandin D synthase (L-PGDS) is implicated in atherogenesis. In the present study, we investigated the polymorphism of the L-PGDS gene and examined its relationship with the severity of carotid atherosclerosis which is determined as the maximum intima-media thickness in the common carotid artery (C-IMT(max)). We identified 6 single nucleotide polymorphisms (SNPs)...
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