Article
TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine.
Immunology - 1 Sept 2004
Babiuk Shawn, Mookherjee Neeloffer, Pontarollo Reno, Griebel Phillip, van Drunen Littel-van den Hurk Sylvia, Hecker Rolf, Babiuk Lorne
Abstract excerpt
Plasmid DNA continues to attract interest as a potential vaccine-delivery vehicle. However, the mechanisms whereby immune responses are elicited by plasmids are not fully understood. Although there have been suggestions regarding the importance of CpG motifs in plasmid immunogenicity, the molecul...
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