Article
Gastrointestinal symptoms and ethanol metabolism in alcoholics.
Digestive diseases and sciences - 1 Jun 2004
Laheij R J E, Verlaan M, Van Oijen M G H, De Doelder M S, Dejong C A J, Jansen J B M J
Abstract excerpt
Excessive alcohol intake frequently results in gastrointestinal discomfort. It is an empirical fact that the severity of gastrointestinal discomfort induced by alcohol abuse is subject to interindividual variation. The aim of this study was to determine whether genetic polymorphism in alcohol dehydrogenase 3 (ADH3) and cytochrome P450 2E1 (CYP2E1), important first-pass enzymes in the metabolism of ethanol,...
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