First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying.

doi:10.1136/gut.43.5.612

Article

First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying.

Gut - 1 Nov 1998

Oneta C M, Simanowski U A, Martinez M, Allali-Hassani A, Parés X, Homann N, Conradt C, Waldherr R, Fiehn W, Coutelle C, Seitz H K

Abstract excerpt

BACKGROUND: Ethanol undergoes a first pass metabolism (FPM) in the stomach and liver. Gastric FPM of ethanol primarily depends on the activity of gastric alcohol dehydrogenase (ADH). In addition, the speed of gastric emptying (GE) may modulate both gastric and hepatic FPM of ethanol. AIMS: To stu...

Topics

Administration, Oral
Adult
Alcohol Dehydrogenase
Ethanol
Female
Gastric Emptying
Gastric Mucosa
Genotype
Humans
Infusions, Intravenous
Liver
Male
Middle Aged
Phenotype

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