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Article

Unbalanced activation of ERK1/2 and MEK1/2 in apigenin-induced HeLa cell death.

Experimental cell research - 10 Sept 2004

Llorens Franc, Miró Francesc A, Casañas Arnau, Roher Nerea, Garcia Lourdes, Plana Maria, Gómez Néstor, Itarte Emilio

Abstract excerpt

Apigenin, a dietary bioflavonoid with anticarcinogenic properties, was highly cytotoxic for HeLa cells (incubated with 0.5% FBS). This effect was accompanied with a marked increase in ERK1/2 but not MEK1/2 phosphorylation. The cytotoxic effects of apigenin were attenuated by the stimulation of these cells with 10% FBS, which provoked an increase in the phosphorylation levels of MEK1/2 and ERK1/2. The steps in the...

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Identifiers

PMID: 15302569
DOI: 10.1016/j.yexcr.2004.05.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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