Article
Does parkin play a role in the peripheral nervous system? A family report.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2004
Abbruzzese Giovanni, Pigullo Simona, Schenone Angelo, Bellone Emilia, Marchese Roberta, Di Maria Emilio, Benedetti Luana, Ciotti Paola, Nobbio Lucilla, Bonifati Vincenzo, Ajmar Franco, Mandich Paola
Abstract excerpt
Two genes were identified for autosomal recessive forms of early onset Parkinson's disease: parkin and DJ-1. We describe 2 siblings with EOPD due to parkin mutations and peripheral neuropathy, which presented as neuropathy with liability to pressure palsies (HNPP) in the index case. RT-PCR experiments revealed that the parkin gene is expressed in sural nerves from both controls and patient with parkin-related...
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