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Article

Pseudo-autosomal dominant inheritance of PARK2: two families with parkin gene mutations.

Journal of the neurological sciences - 15 Mar 2003

Kobayashi Tomonori, Matsumine Hiroto, Zhang JiaLin, Imamichi Yoko, Mizuno Yoshikuni, Hattori Nobutaka

Abstract excerpt

We report two families (Family S and Family N) with early-onset parkinsonism in two generations. The mode of inheritance appeared to be autosomal dominant, however, haplotye analysis suggested linkage to chromosome 6q25.2-27, the PARK2 locus, and all affected members were homozygotes in their haplotypes. In Family S, the affected father was married to unaffected mother, who carried one disease-linked haplotype at...

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PMID: 12614925
DOI: 10.1016/s0022-510x(02)00358-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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