Article
Screen for expanded FMR1 alleles in patients with essential tremor.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2004
Garcia Arocena Dolores, Louis Elan D, Tassone Flora, Gilliam T Conrad, Ottman Ruth, Jacquemont Sébastien, Hagerman Paul J
Abstract excerpt
Fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disorder, was described recently among male carriers of expanded alleles (55-200 CGG repeats; premutation range) of the fragile X mental retardation 1 (FMR1) gene. Major features of the syndrome include intention tremor, gait ataxia, and parkinsonism in men over 50 years of age. This disorder is believed to be relatively common, possibly...
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