Article
Vitamin D receptor start codon polymorphism (FokI) and prostate cancer progression.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2003
Xu Yue, Shibata Atsuko, McNeal John E, Stamey Thomas A, Feldman David, Peehl Donna M
Abstract excerpt
Vitamin D plays an important role in cell growth and differentiation and is proposed to protect against cancer initiation and/or progression. The vitamin D receptor (VDR) has a thymine/cytosine (T/C) polymorphism located in the first of two potential start (ATG) codons that can be detected by a RFLP using the endonuclease FokI. The C variant, which lacks the first ATG, results in a shorter VDR and is referred to...
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