Article
Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2004
Nosrati Mehdi, Li Shang, Bagheri Sepideh, Ginzinger David, Blackburn Elizabeth H, Debs Robert J, Kashani-Sabet Mohammed
Abstract excerpt
PURPOSE: To test ribozymes targeting mouse telomerase RNA (mTER) for suppression of the progression of B16-F10 murine melanoma metastases in vivo. EXPERIMENTAL DESIGN: Hammerhead ribozymes were designed to target mTER. The ribozyme sequences were cloned into a plasmid expression vector containing EBV genomic elements that substantially prolong expression of genes delivered in vivo. The activity of various...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.