Article
Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutants.
The Journal of infectious diseases - 1 Sept 2004
DeVincenzo John P, Hall Caroline B, Kimberlin David W, Sánchez Pablo J, Rodriguez William J, Jantausch Barbara A, Corey Lawrence, Kahn Jeffrey S, Englund Janet A, Suzich JoAnn A, Palmer-Hill Frances J, Branco Luis, Johnson Syd, Patel Nita K, Piazza Franco M
Abstract excerpt
Premature infants and those with chronic lung disease or congenital heart disease are at high risk of severe respiratory syncytial virus (RSV) disease. Palivizumab (Synagis), a humanized anti-RSV monoclonal antibody, has been used extensively since 1998 to prevent severe RSV disease in high-risk infants. To monitor for possible palivizumab-resistant mutants, an immunofluorescence binding assay that predicts...
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