Article
Methylenetetrahydrofolate reductase genotype does not play a role in adult T-cell leukemia/lymphoma pathogenesis among human T-lymphotrophic virus type 1 carriers.
Leukemia research - 1 Oct 2004
Takeuchi Seisho, Takeuchi Naoko, Tsukasaki Kunihiro, Yang Yang, Fermin Anthony C, Tomonaga Masao, Miller Carl W, Seo Hiromi, Koeffler H Phillip
Abstract excerpt
Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL). However, the incidence of ATL is low among HTLV-1 carriers suggesting additional mechanisms are involved in the progression of the disease. A recent study found that polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene influence the susceptibility to malignant lymphoma. We have analyzed the MTHFR...
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