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Article

Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects.

The Journal of clinical investigation - 1 Aug 2004

Borg Christophe, Terme Magali, Taïeb Julien, Ménard Cédric, Flament Caroline, Robert Caroline, Maruyama Koji, Wakasugi Hiro, Angevin Eric, Thielemans Kris, Le Cesne Axel, Chung-Scott Véronique, Lazar Vladimir, Tchou Isabelle, Crépineau Florent, Lemoine François, Bernard Jacky, Fletcher Jonhantan A, Turhan Ali, Blay Jean-Yves, Spatz Alain, Emile Jean-François, Heinrich Michael C, Mécheri Salah, Tursz Thomas, Zitvogel Laurence

Abstract excerpt

Mutant isoforms of the KIT or PDGF receptors expressed by gastrointestinal stromal tumors (GISTs) are considered the therapeutic targets for STI571 (imatinib mesylate; Gleevec), a specific inhibitor of these tyrosine kinase receptors. Case reports of clinical efficacy of Gleevec in GISTs lacking...

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Source

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Identifiers

PMID: 15286804
DOI: 10.1172/JCI21102
PMCID: PMC489961

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15286804-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects.PMID 15286804Read ↗

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