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Article

Structural insight into the cooperativity between catalytic and noncatalytic sites of F1-ATPase.

Biochimica et biophysica acta - 23 Jul 2004

Falson Pierre, Goffeau André, Boutry Marc, Jault Jean-Michel

Abstract excerpt

F1-ATPase, the catalytic sector of Fo-F1 ATPases-ATPsynthases, displays an apparent negative cooperativity for ATP hydrolysis at high ATP concentrations which involves noncatalytic and catalytic nucleotide binding sites. The molecular mechanism of such cooperativity is currently unknown. To get further insights, we have investigated the structural consequences of the single mutation of two residues: Q173L in the...

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PMID: 15282184
DOI: 10.1016/j.bbabio.2004.05.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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