Article
Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis.
Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2004
Yamashita Kentaro, Shinohara Miki, Shinohara Akira
Abstract excerpt
An E2 ubiquitin-conjugating enzyme, Rad6, working with an E3 ubiquitin ligase Bre1, catalyzes monoubiquitylation of histone H2B on a C-terminal lysine residue. The rad6 mutant of Saccharomyces cerevisiae shows a meiotic prophase arrest. Here, we analyzed meiotic defects of a rad6 null mutant of budding yeast. The rad6 mutant exhibits pleiotropic phenotypes during meiosis. RAD6 is required for efficient formation...
Topics
- DNA-Binding Proteins
- Endodeoxyribonucleases
- Esterases
- Histones
- Meiosis
- Mitosis
- Mutation
- Rad51 Recombinase
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription Factors
- Ubiquitin
- Ubiquitin-Conjugating Enzymes