Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer.

doi:10.1016/j.dnarep.2004.03.036

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Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer.

DNA repair - 1 Jan 2000

Halazonetis Thanos D

Abstract excerpt

If the major function of the p53 protein is to function as a DNA damage checkpoint protein, then it is reasonable to hypothesize that its inactivation in human cancer must be related to its DNA damage checkpoint function. This hypothesis further implies that in tumor cells one or more of the DNA damage checkpoint pathways has been activated. Otherwise, p53 would not be active and there would be no selective...

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