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Article

The adenovirus priming protein pTP contributes to the kinetics of initiation of DNA replication.

Nucleic acids research - 1 Jan 2004

Mysiak Monika E, Holthuizen P Elly, van der Vliet Peter C

Abstract excerpt

Adenovirus (Ad) precursor terminal protein (pTP) in a complex with Ad DNA polymerase (pol) serves as a primer for Ad DNA replication. During initiation, pol covalently couples the first dCTP with Ser-580 of pTP. By using an in vitro reconstituted replication system comprised of purified proteins, we demonstrate that the conserved Asp-578 and Asp-582 residues of pTP, located close to Ser-580, are important for the...

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Identifiers

PMID: 15273278
DOI: 10.1093/nar/gkh726
PMCID: PMC506811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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