Article
Farnesylation of YDJ1p is required for function at elevated growth temperatures in Saccharomyces cerevisiae.
The Journal of biological chemistry - 15 Sept 1992
Caplan A J, Tsai J, Casey P J, Douglas M G
Abstract excerpt
The Saccharomyces cerevisiae YDJ1 protein (YDJ1p) contains a C-terminal "CaaX box" motif common to proteins that are modified by prenylation. In the present study we show that YDJ1p is a specific substrate for both yeast and mammalian protein farnesyltransferase enzymes in vitro. A mutant form of YDJ1p, in which the conserved cysteine of the CaaX box is mutated to a serine (ydj1-S406p), cannot be farnesylated in...
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