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Article

Does bilirubin protect against hemochromatosis gene (HFE) related mortality?

American journal of medical genetics. Part A - 15 Aug 2004

Alizadeh Behrooz Z, Njajou Omer T, Houwing-Duistermaat Jeanine J, de Jong Gerard, Vergeer Jeannette M, Hofman Albert, Pols Huibert A P, van Duijn Cornelia M

Abstract excerpt

Serum bilirubin is an important antioxidant that is found at increased levels in hereditary hemochromatosis patients. We hypothesized that increased levels of serum bilirubin may play a protective role against oxidative stress induced by iron overload in carriers of mutations in the hereditary hemochromatosis gene (HFE). We studied the relation between serum total bilirubin, serum iron levels, the HFE C282Y and...

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Source

Identifiers

PMID: 15266614
DOI: 10.1002/ajmg.a.30163

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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