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Article

Derepression by depolymerization; structural insights into the regulation of Yan by Mae.

Cell - 23 Jul 2004

Qiao Feng, Song Haiyun, Kim Chongwoo A, Sawaya Michael R, Hunter Jacob B, Gingery Mari, Rebay Ilaria, Courey Albert J, Bowie James U

Abstract excerpt

Yan, an ETS family transcriptional repressor, is regulated by receptor tyrosine kinase signaling via the Ras/MAPK pathway. Phosphorylation and downregulation of Yan is facilitated by a protein called Mae. Yan and Mae interact through their SAM domains. We find that repression by Yan requires the formation of a higher order structure mediated by Yan-SAM polymerization. Moreover, a crystal structure of the...

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PMID: 15260987
DOI: 10.1016/j.cell.2004.07.010

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