Article
Screening cord blood for hemoglobinopathies and thalassemia by HPLC.
Clinical chemistry - 1 Sept 1992
van der Dijs F P, van den Berg G A, Schermer J G, Muskiet F D, Landman H, Muskiet F A
Abstract excerpt
We evaluated the use of an HPLC method for screening hemoglobins in cord blood. We studied the genotype frequencies of the structural hemoglobin variants HbS and HbC and the synthesis variants alpha- and beta(+)-thalassemia in babies born on Curaçao. During three months, 67.2% of all (748) newborns were screened: 122 (24.3%) had an abnormal hemoglobin pattern, of which 53 (43.4%) had a hemoglobinopathy (HbS or...
Topics
- Chromatography, High Pressure Liquid
- Evaluation Studies as Topic
- Fetal Blood
- Gene Frequency
- Genotype
- Hemoglobinopathies
- Hemoglobins, Abnormal
- Heterozygote
- Humans
- Infant, Newborn
- Mass Screening