Article
Hb Bart's in cord blood: an accurate indicator of alpha-thalassemia.
Hemoglobin - 1 Jan 2006
Rugless Michelle J, Fisher Chris A, Stephens Adrian D, Amos Roger J, Mohammed Tanwir, Old John M
Abstract excerpt
We quantified Hb Bart's (gamma4) levels by high performance liquid chromatography (HPLC) in 103 fresh cord blood samples from Homerton Hospital, East London, UK. The alpha-globin gene arrangement was determined by Southern blot hybridization and genomic sequence analysis of the alpha-globin genes. The cord blood Hb Bart's levels ranged from 0.5 to 11.9% of total hemoglobin (Hb) and were arranged into three...
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