Article
N(omega)-nitro-L-arginine methyl ester effects on neutrophil function and bacterial clearance.
Shock (Augusta, Ga.) - 1 Aug 2004
Stehr Sebastian N, Weber Sören, Heller Susanne C, Weikel Jutta, Hübler Matthias, Koch Thea, Heller Axel R
Abstract excerpt
Nitric oxide synthase (NOS) inhibitors are considered promising as a therapeutic option in severe septic shock. The aim of this study was to investigate the effects of N-nitro-L-arginine methyl ester (L-NAME) application on neutrophil (PMN) respiratory burst, phagocytosis, and elimination of Escherichia coli from blood and tissue in rabbits. Twenty-eight female chinchilla rabbits were randomized to a treatment...
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