Article
On the origin of the electrostatic barrier for proton transport in aquaporin.
FEBS letters - 16 Jul 2004
Burykin Anton, Warshel Arieh
Abstract excerpt
The nature of the electrostatic barrier for proton transport in aquaporins is analyzed by semimacroscopic and microscopic models. It is found that the barrier is associated with the loss of the generalized solvation energy upon moving from the bulk solvent to the center of the channel. It is clarified that our solvation concept includes the effect of the protein polar groups and ionized residues. The nature of...
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