Article
Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease.
Annals of the New York Academy of Sciences - 1 Jun 2004
Lee Hyoung-Gon, Casadesus Gemma, Zhu Xiongwei, Takeda Atsushi, Perry George, Smith Mark A
Abstract excerpt
Ever since their initial description over a century ago, senile plaques and their major protein component, amyloid-beta, have been considered key contributors to the pathogenesis of Alzheimer disease. However, counter to the popular view that amyloid-beta represents an initiator of disease pathogenesis, we herein challenge dogma and propose that amyloid-beta occurs secondary to neuronal stress and, rather than...
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