Article
Molecular genotyping of a large, multicentric collection of tubercle bacilli indicates geographical partitioning of strain variation and has implications for global epidemiology of Mycobacterium tuberculosis.
Journal of clinical microbiology - 1 Jul 2004
Ahmed Niyaz, Alam Mahfooz, Rao K Rajender, Kauser Farhana, Kumar N Ashok, Qazi Nazia N, Sangal Vartul, Sharma V D, Das Ram, Katoch V M, Murthy K J R, Suneetha Sujai, Sharma S K, Sechi Leonardo A, Gilman Robert H, Hasnain Seyed E
Abstract excerpt
Tuberculosis continues to be a major killer disease, despite an all-out effort launched against it in the postgenomic era. We describe here the population structure of Mycobacterium tuberculosis strains, as revealed by a chromosome-wide scan of fluorescent amplified fragment length polymorphisms (FAFLPs), for more than 1,100 independent isolates from 11 different countries. The bacterial strains were genotyped...
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