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Article

Association of Otosclerosis With Sp1 Binding Site Polymorphism in COL1A1 Gene: Evidence for a Shared Genetic Etiology With Osteoporosis

30 Jun 2004

Abstract excerpt

HYPOTHESIS: There is an association between otosclerosis and osteoporosis. BACKGROUND: Both osteoporosis and otosclerosis are common bone diseases to which relatively large portions of the population are genetically predisposed. Recently, a strong association has been described between osteoporosis and an Sp1 binding site of putative functional significance in the first intron of the COL1A1 gene. METHODS: We...

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PMID: 15241219
DOI: 10.1097/00129492-200407000-00008

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Association of Otosclerosis With Sp1 Binding Site Polymorphism in COL1A1 Gene: Evidence for a Shared Genetic Etiology With OsteoporosisPMID 15241219Read ↗

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