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Article

New PCR-based method for the Sp1 site polymorphism in the COL1A1 gene.

Clinical chemistry and laboratory medicine - 1 Jul 2001

Vinkanharju A, Melkko T, Risteli J, Risteli L

Abstract excerpt

Polymorphism in the Sp1 binding site in the first intron of the COL1A1 gene has been related to increased risk of osteoporosis in several populations. To overcome the difficulties associated with the use of mismatch oligonucleotide primers in the original method for its detection, we developed a procedure involving PCR amplification of a 598-base pair sequence from the intron and its digestion with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11522109
DOI: 10.1515/CCLM.2001.100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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