Article
Maternal genotype can influence the outcome of a study on mutant animals.
Annals of the New York Academy of Sciences - 1 Jun 2004
Zelena Dóra, Mergl Zsuzsa, Makara Gábor B
Abstract excerpt
The hypothalamo-pituitary-adrenal (HPA) axis plays a crucial role in stress. One of its central regulatory components is arginine-vasopressin (AVP). We studied the role of AVP in acute restraint in AVP-deficient mutant Brattleboro rats (AVP-), but our results were variable. The early life period is important in the later stress reactivity of the animals. We realized that our AVP- pups could be born from AVP+...
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