Article
Yellow fever 17DD vaccine virus is temperature sensitive when grown in mosquito C6-36 cells.
Vaccine - 1 Jan 1992
Ledger T N, Sil B K, Dunster L M, Stephenson J R, Minor P D, Barrett A D
Abstract excerpt
Twenty-three yellow fever (YF) vaccine viruses and three wild-type YF viruses were propagated independently in human adenocarcinoma (SW13) cells and mosquito Aedes albopictus C6-36 cells. The three YF 17DD vaccine viruses were found to be slightly temperature sensitive (ts) at 39.5 degrees C versus 37.0 degrees C (efficiency of plaquing 0.04 to 0.1) following propagation in C6-36 but not in SW13 cells. A...
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