Article
Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity.
Experimental gerontology - 1 Jul 2004
Barbieri Michelangela, Bonafè Massimiliano, Rizzo Maria Rosaria, Ragno Emilia, Olivieri Fabiola, Marchegiani Francesca, Franceschi Claudio, Paolisso Giuseppe
Abstract excerpt
Long-lived subjects have been shown to have peculiar anthropometric features (i.e. lower body mass index (BMI)) and metabolic parameters (i.e. improved insulin sensitivity). Life style and a genetic background potentially protective against the age-related metabolic derangement might contribute to such a particular phenotype. Peroxisome proliferator-activated receptor (PPAR)gamma-2 is an important regulator of...
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